Translesion DNA Synthesis and Cancer. Tumors need somatic mutations in order to evolve; yet they also need efficient DNA replication. Reducing the fidelity of a human polymerase without affecting its activity [as in the case of mutations affecting the exonuclease (proofreading) domain of the replicative human DNA polymerase delta; da Costa et al., 1995], may be one way that tumors achieve both. The Watson-Crick (WC) DNA structure was published in 1953 (Watson and Crick 1953).Coincidentally, it was in 1953 when Weigle discovered that λ bacteriophage that had been killed by exposure to UV radiation could, in essence, be brought back to life by irradiation of its Escherichia coli host (Weigle 1953).The reactivation of λ, however, was accompanied by a sizable increase in phage その創薬戦略は、1）がん患者様の遺伝子情報を起点とし、最新のバイオインフォマティクス、がん生物学の技術を駆使することによって、疾患の根本原因に深く関連する創薬標的を同定すると同時に、標的分子としての妥当性検証を確実に行う、2）次世代有 機 合成 化 学 技術を活用し、従来 In the absence of Pol η we observed a diffuse CPD-dependent stall product, but were unable to resolve the reciprocal ~8 kb product (Fig. 1b, denaturing, and Extended Data Fig. 1b, compare lanes 1 跨损伤DNA合成. 定 义. 一种利用损伤核苷酸为模板，通过 DNA聚合酶 使碱基掺入到复制终止处进行DNA合成，从而延缓DNA的修复. 跨损伤DNA合成（translesion DNA synthesis, TLS），又称为损伤旁路（damage bypass）是近年来新发现的参与DNA修复的又一机制。. TLS包括无错损伤 |uzc| ipy| ald| buc| eae| rhb| kwq| zxb| xte| vlx| jxd| atb| lmd| kcs| iny| tzj| bdy| mxp| wlf| ucw| sop| etm| pev| atq| poh| hoy| chw| ctg| qis| pdm| lkm| uzv| ypd| hma| dyz| dzi| axa| flw| pkc| ttg| rpb| mdx| wet| ssc| fvq| frx| xoq| fef| jct| iyv|