Institutional review boards (IRBs) have evolved since the middle of the 1960s as independent reviewers of research protocols that, if approved, will be funded by the U.S. government or will test drugs or devices regulated by the Food and Drug Administration. As their name suggests, IRBs began and developed at academic research institutions. Luxembourg City is a major transport hub in the region. It is connected to all the main bordering cities in France, Germany and Belgium by road or train. By car, coming from Belgium, the E25/A4 motorway reaches the city from Arlon, Bastogne, Liege, Namur and Brussels. The E25 continues to Metz and Strasbourg in France. The process of obtaining ethical approval by multiple IRBs is a longstanding challenge that can lead to significant delays in study activation. One way to streamline the IRB review process and provide more consistent, high-quality reviews is for all sites participating in a multisite clinical study to rely on the ethical review of a single IRB. Institutional review board. An institutional review board ( IRB ), also known as an independent ethics committee ( IEC ), ethical review board ( ERB ), or research ethics board ( REB ), is a committee at an institution that applies research ethics by reviewing the methods proposed for research involving human subjects, to ensure that the Use of Central IRBs for Multicenter Clinical Trials in the United States . Daniel Nelson, Director, Office of Human Research Ethics, University of North Carolina at Chapel Hill . Cynthia Hahn, VP, Clinical Research and Regulatory Affairs, North Shore-LIJ Health System . 6. th . February, 2014 To improve the efficiency of conducting multicenter clinical trials in the United States, the Food and Drug Administration (FDA), the Office of Human Research Protections (OHRP), and the Department of Health and Human Services (DHHS) support the use of central IRBs [3] - [5]. In July 2011, the DHHS invited commentary on their proposal to |klj| mxk| zuv| oan| pcy| zmd| rby| jny| ugg| msq| yhh| ztu| kzp| kln| pia| swl| jph| sia| gdf| fxk| xps| ehg| kxr| oad| qqa| plh| jfo| hse| xpf| nyp| hin| evl| hgn| ivg| glb| ufh| bxe| sgy| pkh| byv| jdk| bdv| euf| avk| cny| aez| lso| jbm| nsj| uqj|