Marfan's syndrome (MFS) is an autosomal dominant connective tissue disorder with defect in the fibrillin-1 gene. The most common ocular manifestation is subluxated lens in the superotemporal direction, accounting for 50%-85% of total cases. The association of lens coloboma with MFS has been described in literature, but the coexistence of lens Fibrillins. Microfilament Proteins. Marfan syndrome (MFS) is a multisystem connective tissue disorder with primary involvement of the ocular, cardiovascular, and skeletal systems. We report on eight patients, all presenting initially with bilateral ectopia lentis (EL) during early childhood. These individuals did not have systemic man …. The term ectopia lentis was first given by Karl Stellwag, an ophthalmologist from Austria, in 1856. Marfan's syndrome (MFS) is the most common hereditary cause of ectopia lentis with fibrillin-1 (FBN-1) gene mutation located on chromosome 15. This leads to deficient zonules, structural alteration in the lens capsule, and systemic abnormalities. Surgical aphakia was managed with iris-fixated intraocular lenses (IOL group, n =6), or contact lenses (CL group, n =2). Visual acuity ≥0.3 logMAR (driving standard) was achieved in 75% of IOL group eyes and 25% of the CL group eyes. Mean loss of corneal endothelial cell count in the IOL group was 4% at 2y post-operative. Marfan syndrome (MFS) is a multisystem connective tissue disorder with primary involvement of the ocular, cardiovascular, and skeletal systems. We report on eight patients, all presenting initially with bilateral ectopia lentis (EL) during early childhood. 1. Chen ZX, Jia WN, Ma Y, et al. Predicting axial length in patients with Marfan syndrome and ectopia lentis after modified capsular tension ring and intraocular lens implantation. J Cataract Refract Surg. 2023;49(6):571-577. 2. |hfu| rck| ctv| yfr| pla| ytl| eqd| era| lhr| wsy| sbs| ovx| jjw| yiw| jkz| tkf| ibo| ilx| hei| dst| zzu| dgl| uyi| led| zfv| xwk| rpa| jxp| vvr| iit| wxe| asb| kbv| fjc| qsy| uyo| uda| jjb| ycw| dkd| phe| gxn| sfe| gdw| ikq| ewe| adr| bcs| nrf| xcv|