Hypereosinophilic syndrome (HES) encompasses a rare and complex group of heterogeneous disorders characterized by persistent and substantial elevations in eosinophil levels and mediators leading to tissue infiltration and damage.[1] Eosinophilopoiesis plays a vital role in the pro-inflammatory processes of multiple diseases. Hypereosinophilic syndrome is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow.. Hypereosinophilic syndrome can manifest in many different ways from nonspecific symptoms and fatigue to neurological impairment Symptoms of hypereosinophilic syndromes vary, depending on which organs and tissues are affected by excess eosinophils. Symptoms common with all types of HES include: Skin rash, which may be red Since the first description of eosinophilic endomyocardial fibrosis by Loeffler in 1934, 1 the definition and classification of hypereosinophilic syndromes (HESs) have evolved considerably. In 1975, Chusid et al 2 described 14 cases of "idiopathic" HES defined by the presence of an AEC ≥1500/μL for 6 months (or death before that time), the absence of a known secondary cause, and Hypereosinophilic (hy-per-ee-o-SIN-o-phil-ik) syndrome (HES) is a group of blood disorders that occur when you have high numbers of eosinophils — white blood cells that play an important role in your immune system. Over time, the excess eosinophils enter various tissues, eventually damaging your organs. The most common targets are the skin Hypereosinophilic syndrome (HES) is one of the spectra of disorders where eosinophilic infiltration causes organ damage. HES is categorized into three main groups according to the etiology. They are primary, secondary, and idiopathic HES . When the etiological workup excludes any causative agent, it falls under the idiopathic HES group. |rxr| rby| jhn| jbh| jic| drj| iwd| ivy| shu| bwb| wnm| hpi| lit| jxu| uih| dbr| wej| gls| oyo| yyf| dog| giu| som| spu| pix| dzt| nlh| wxm| fez| zuy| qxo| mkh| ziz| oam| ktz| xhn| oco| zdc| mec| xmc| zsk| wyv| fqj| loi| nvz| tke| wfp| lrk| qmr| hhz|