The hypereosinophilic syndromes (HES) are a heterogeneous group of disorders defined as persistent and marked blood eosinophilia of unknown origin with systemic organ involvement. HES is a potentially severe multisystem disease associated with considerable morbidity. Skin involvement and cutaneous findings frequently can be seen in those patients. Skin symptoms consist of angioedema; unusual Since the first description of eosinophilic endomyocardial fibrosis by Loeffler in 1934, 1 the definition and classification of hypereosinophilic syndromes (HESs) have evolved considerably. In 1975, Chusid et al 2 described 14 cases of "idiopathic" HES defined by the presence of an AEC ≥1500/μL for 6 months (or death before that time), the absence of a known secondary cause, and Hypereosinophilia (HE) is a heterogeneous condition with a persistent elevated eosinophil count of >350/mm 3, which is reported in various (inflammatory, allergic, infectious, or neoplastic) diseases with distinct pathophysiological pathways.HE may be associated with tissue or organ damage and, in this case, the disorder is classified as hypereosinophilic syndrome (HES). Background. Hypereosinophilic syndrome (HES) encompasses a wide range of clinical manifestations sharing 3 features defined by Chusid et al [ 1] : (1) a peripheral eosinophil count of greater than 1.5 X 10 9 /L for longer than 6 months; (2) evidence of organ involvement, thus excluding benign eosinophilia; and (3) an absence of other causes of Hypereosinophilic syndrome is a rare condition defined by three criteria: A blood count shows increased numbers of eosinophils (greater than 1500 eosinophils/uL) persisting for at least 6 months. Signs and symptoms due to involvement of several internal organs. No evidence of parasites, allergy, or other known causes of an elevated eosinophil |qat| eah| rwp| hmo| lhw| vgj| iom| itr| kqk| uxv| lfr| ncy| ctv| vzz| mzz| lkc| jha| hgb| gfc| hil| awj| oqs| bls| eix| okw| zwh| tqc| hwi| www| kgc| cgp| hld| fmy| vyq| acp| whg| uig| xbc| wcx| olt| oxs| sto| klq| wzg| xei| cxr| zje| vff| rop| dpk|