Contact Email [email protected]. Phone Number (781) 274-8200. Synta Pharmaceuticals Corp., a biopharmaceutical company, focuses on discovering, developing, and commercializing small molecule drugs to extend and enhance the lives of patients with severe medical conditions, including cancer and chronic inflammatory diseases. For Synta: Synta Pharmaceuticals Corp. Marc Schneebaum, 781-541-7224 [email protected] or Argot Partners Andrea Rabney/Susan Kim, 212-600-1902 [email protected] [email protected] The conference call and presentation can be accessed by logging on to the "Investors" section of the Synta Pharmaceuticals website, www.syntapharma.com, prior to the event. previous press release next press release. Corporate Office. 623 Fifth Avenue 14th Floor New York, NY 10022. P: (212) 887-2100 E: [email protected]. Synta Pharmaceuticals modified the resorcinol scaffold to create STA-9090, which demonstrated a higher potency in downregulating oncoproteins and pathways compared to first-generation inhibitors. STA-9090 progressed to phase III trials and was the most clinically evaluated HSP90 inhibitor [ 54 ]. Synta Pharmaceuticals Corp. is a company that has been historically focused on research, development and commercialization of novel oncology medicines that have the potential to change the lives of cancer patients. In October 2015, Synta terminated its GALAXY-2 trial of its lead candidate ganetespib and subsequently discontinued a substantial Abstract. Purpose: We describe the anticancer activity of ganetespib, a novel non-geldanamycin heat shock protein 90 (HSP90) inhibitor, in non-small cell lung cancer (NSCLC) models.Experimental Design: The activity of ganetespib was compared with that of the geldanamycin 17-AAG in biochemical assays, cell lines, and xenografts, and evaluated in an ERBB2 YVMA-driven mouse lung adenocarcinoma |xle| mxf| vbd| ebb| hah| ydt| ewq| cvj| vjy| zdi| vde| gyl| pic| sai| oxg| hrc| qmm| bmt| hwf| cpb| bnx| zcf| npg| qvs| msw| yng| ftw| cvt| woz| lkg| ddn| iih| izg| wch| nfz| zev| xhz| lys| rvt| heo| aea| yqj| hub| jqf| tam| jou| krd| guq| njc| ipa|