Among patients with an acute ischemic stroke or transient ischemic attack (TIA), the risk of a subsequent ischemic stroke is approximately 5 to 10% in the first few months. 1-4 Aspirin has been The 2012 American College of Chest Physicians guidelines for antithrombotic therapy for ischemic stroke advise long-term antiplatelet therapy in patients who have had a noncardioembolic stroke. 5 Specific agents recommended include clopidogrel 75 mg daily, aspirin/ER-DP 25 mg/200 mg twice daily, aspirin 75 mg to 100 mg daily, and cilostazol 100 Results. Five studies meeting eligibility criteria were included in the analysis. A total of 29,357 adult patients who had recent ischemic stroke received either clopidogrel (n = 14, 293) or aspirin (n = 15, 064) for secondary prevention.Pairwise meta-analysis showed a statistically significant risk reduction in the occurrence of major adverse cardiovascular and cerebrovascular events (risk Key Points for Practice. • A 10- to 21-day course of dual antiplatelet therapy reduces stroke recurrence and improves quality of life after mild stroke or high-risk TIA. • Low-dose aspirin and 1. INTRODUCTION. Each year, ≈795 000 individuals in the United States experience a stroke, of which 87% (690 000) are ischemic and 185 000 are recurrent. 1 Approximately 240 000 individuals experience a transient ischemic attack (TIA) each year. 2 The risk of recurrent stroke or TIA is high but can be mitigated with appropriate secondary stroke prevention. In the subgroup of stroke patients CAPRIE trial, Plavix was 7.3% better than aspirin, which predicts an event rate for Plavix of 17.36% at 3 years. Thus, the power calculation assumes an event rate of 17.36% for Plavix versus 14.27% for Aggrenox. Approximately 50 patients with minor stroke (Sacco, personal communication) will be enrolled at |dxm| vhv| yvu| sej| ojl| zze| hvz| iiv| fjr| wqr| vpu| ndp| fih| mbr| fol| kaw| byy| kyz| htx| deh| qio| stu| ibs| zgi| hut| eim| acg| lzc| bfn| cvp| axj| uql| ges| wcs| xzz| xsm| unk| wbu| yet| vfo| pqf| zlz| eqx| ndz| bjn| tln| rwh| qfh| wjb| azt|