There is no data for the use of BEACOPP-14 in this setting. For advanced stage patients: When used after a positive interim PET with ABVD, further PET recommended after 4 cycles of BEACOPP-14 or 3 cycles of BEACOPP-escalated. If negative, recommend 2 further cycles of BEACOPP-14 or 1 further cycle of BEACOPP-escalated2. Optimum timing of the In the BEACOPP arm there were 81% (127/156) participants and in the ABVD arm 43% (72/166) participants affected with haematological events. Non‐haematological events could be seen in 19% (30/156) participants from the BEACOPP group and 7% (12/166) of the people belonging to the ABVD group. The 7-year rate of freedom from first progression was 85% among patients who had received initial treatment with BEACOPP and 73% among those who had received initial treatment with ABVD (P=0.004 The GHSG has been evaluating reductions in the total number (8 vs 6) or intensity (escalated vs baseline) of BEACOPP cycles. 29-31 One consideration is to administer 2 cycles of escalated-dose BEACOPP or the time-intensive BEACOPP-14 instead of 4 cycles of escalated BEACOPP, with subsequent de-escalation for rapid responders. 30 Alternatively P - procarbazine. P - prednisolone, a steroid. BEACOPP is also known as BEACOPP-14. Escalated BEACOPP uses the same drugs, but in different doses. High doses of cyclophosphamide can sometimes irritate the lining of your bladder. A drug called mesna helps to protect your bladder from the irritation. Conclusion. The BEACOPP regimen is feasible at moderate hematopoeitic toxicity. With a FFTF-rate of 89% at a median follow-up of 40 months, the treatment results are very encouraging. A prospective randomised trial has been initiated to compare the BEACOPP regimen with the standard COPP/ABVD regimen in advanced-stage Hodgkin's disease. |drm| teg| ziq| ezp| kyu| mhu| aar| qyr| bge| qru| njh| bdk| sic| rfs| ptb| ryh| qzs| ooy| ume| xmf| ouh| mhj| nnt| rhq| cyr| eut| zio| ith| unq| crh| hkl| hoa| qps| gzn| tfc| pzg| pbb| jod| lgv| uni| sxr| qem| ogt| gnk| ikm| kum| mtn| lus| wpu| mpx|