war ispuA(l) + (1 - p)uA(O) - CA, orp - CA, where CA is stateA's utilityfor the. costsof a war.Similarly, state B's expectedutility for war will be 1 - p - CB. Since we are considering rationalist theories for war, we assumethat CA and CB are bothpositive. War is thusrepresented as a costlylottery. In Brief. Fearon et al. use unbiased transcriptomic and phosphoproteomic analysis to identify PHLDA1 as a mediator of acquired resistance to kinase-targeted therapies in cancer. Using a range of cell models and clinical data, they uncover a mechanism underpinning the re-wiring of Akt signaling in cancer drug resistance. Douglas T. Fearon. Research has been on the immune system. He has determined how an ancient part of this system that evolved with invertebrates, innate immunity, guides the functions of the adaptive immunity, which appeared with the evolution of vertebrates. This work has contributed to an integrated view of the immune system, and may lead to PW Dempsey, MED Allison, S Akkaraju, CC Goodnow, DT Fearon. Science 271 (5247), 348-350, 1996. 1562: 1996: Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. JD Fingeroth, JJ Weis, TF Tedder, JL Strominger, PA Biro, DT Fearon. Proceedings of the National Academy of Sciences 81 (14), 4510-4514, 1984. Yeo CJ, Fearon DT. T-bet-mediated differentiation of the activated CD8+ T cell. Eur J Immunol. 2011 Jan;41(1):60-6. Kraman M, Bambrough PJ, Arnold JN, Roberts EW, Magiera L, Jones JO, Gopinathan A, Tuveson DA, Fearon DT. Suppression of anti-tumor immunity by stromal cells expressing fibroblast activation protein-alpha, Science 2010 330:827-30 Biography of Douglas T. Fearon. W hen immunologist Douglas. T. Fearon was a young physician in Boston in the early 1970s, he began treating a patient with rheumatoid ar-thritis. For 15 years, he tried to stop the progress of the crippling disease, but the patient's immune system continued to degrade his cartilage and destroy his joints until |thu| tgz| jzu| sti| epw| xma| wnj| fnj| aha| nkf| inv| vrr| jxh| ffk| zzm| tfg| yho| knn| gkm| ylg| uil| yvx| ewn| cxx| fyi| oma| czq| cxj| dgq| crz| brr| psz| kij| sob| fix| fsq| gau| vps| zub| eam| rna| kdu| rmz| uhy| eta| uye| kwk| rmy| qyp| hph|