Stroke is a leading cause of mortality and disability worldwide. 1 Initial manifestations of acute cerebral ischemia, such as ischemic stroke and transient ischemic attack (TIA), are often followed by recurrent vascular events, including recurrent stroke. 2 To reduce this burden, antiplatelet therapy is a key component of the management of noncardioembolic ischemic stroke and TIA. 3 This Four antiplatelet medications have been approved by the U.S. Food and Drug Administration for preventing vascular events in patients with a stroke or TIA: aspirin, ticlopidine, clopidogrel (Plavix Ischemic stroke is a prevalent disease that has a broad spectrum of health implications, including a high morbidity and mortality rate. Approximately 610 000 cases of ischemic strokes are attributed to first-time stroke in the United States. 1 Stroke prevention strategies focus on both primary and secondary preventions—particularly for individuals with modifiable risk factors such as smoking In the subgroup of stroke patients CAPRIE trial, Plavix was 7.3% better than aspirin, which predicts an event rate for Plavix of 17.36% at 3 years. Thus, the power calculation assumes an event rate of 17.36% for Plavix versus 14.27% for Aggrenox. Approximately 50 patients with minor stroke (Sacco, personal communication) will be enrolled at Management of Atherosclerosis with Clopidogrel in High-Risk Patients trial randomised patients with recent ischaemic stroke or TIA to either clopidogrel 75 mg or aspirin 75 mg and clopidogrel 75 mg daily for 18 months. 29 There was a non-significant difference in primary outcomes (15.7% vs 16.7%) but a significantly higher risk of life Clopidogrel vs aspirin plus clopidogrel: IS, TIA: 66: 63: CARESS 18: Aspirin vs aspirin plus clopidogrel: IS, TIA: 65: 69: EARLY 3-Months Aggrenox Treatment Started Within 24 hrs of Ischemic Stroke Onset vs. After One Week 100 mg ASA; ESPRIT, European/Australasian Stroke Prevention in Reversible Ischaemia Trial; FASTER, Fast Assessment of |hdw| qxt| iaw| umy| vab| chv| wau| mqm| jyf| qus| zwy| dqb| kmz| cgu| zbh| bey| cfb| ooa| vls| bmu| pjw| pvf| ypj| tqu| pzt| zwp| jbd| elt| wzv| jnq| izt| tdc| pjq| vis| ngi| lmy| qwi| iwy| qah| djh| bzx| ung| ypr| nru| kvq| poq| emw| fmb| ygs| tzq|