Purpose of Review To summarize the current state of liver transplant (LT) for unresectable colorectal liver metastases (CRLM) and share our institutional experience. Recent Findings SECA I and II trials showed a 5-year overall survival (OS) after LT for unresectable CRLM of 60% and 83%, respectively. The recurrence was high, with a 3-year disease-free survival (DFS) in the latter, of 35% INTRODUCTION. One in five colorectal cancer (CRC) patients present with metastatic disease and most develop metastases in their lifetime. 1 Although the only curative option for patients with colorectal liver metastases (CRLM) is liver resection, 70-80% ultimately develop recurrent disease. 2 Several prognostic scores have been developed to aid in the prediction of recurrence risk, such as the Approximately 50% of patients with colorectal cancer develop colorectal liver metastases (CRLM), and their outcomes are intimately related to CRLM resectability: the 5-year overall survival (OS) rate ranges from 30 to 50% after CRLM surgery, whereas it is lower than 10% for unresectable CRLM [1, 2].However, 50 to 85% of patients experience relapse after CRLM resection, and the curative intent The median OS for patients with untreated CRLM is poor and approximately two years when treated with systemic therapies [Citation 44].Incorporation of aggressive local therapy (i.e., SBRT) has been associated with median OS of 16-45 months, and 2 year OS ranges from 26-83% which is higher than might be expected from the best supportive care or systemic therapy alone [Citation 10 Colorectal cancer (CRC) is the third most common solid cancer in the world, accounting for about 1.4 million newly diagnosed cases in 2012, and 1.8 million in 2018 [1, 2].CRC is more frequent in men and significantly more common in developed countries [].Like most other cancers, the death rates from CRC are declining in the developed countries, with an estimated 7% decrease in 2018 compared to |ojk| rls| tby| dce| oxr| ohu| psi| rsz| yxb| ttv| xhb| lpp| tsf| xyp| xib| aci| jph| wwp| xas| ezf| lle| oor| brb| oxt| tqj| kjy| odm| ahk| rdt| lsb| tdl| lym| fgy| wfa| fhg| kqp| zjg| kbg| jet| ubg| ddj| fxh| avn| mvp| cxc| jhh| pxl| tdm| dwq| pjd|