fenner, f, studies in mousepox (infectious ectromelia of mice) .5. closed epidemics in herds of normal and vaccinated mice, australian journal of experimental biology and medical science 27: 19 (1949). google scholar. fenner, f, studies in mousepox (infectious ectromelia of mice) .6. Mousepox as a model of smallpox. Mousepox has at least four features similar to smallpox (Figure 1).First, a relatively small dose of virus is required to initiate disease in the upper and lower respiratory tract (although the actual dose required to initiate smallpox is unknown, it is generally accepted to be a low dose []).Second, following a low dose intranasal (IN) infection there is no Observatoire Régional de la Santé Rhône-Alpes. Espace Régional de Santé Publique - 9, quai Jean Moulin 69001 LYON Tél : 04 72 07 46 20 - Fax : 04 72 07 46 21 - Email : [email protected] Site Internet : www.ors-rhone-alpes.org.Ectromelia virus (ECTV) is a natural pathogen of mice that causes mousepox, and many of its genes have been implicated in the modulation of host immune responses. Serine protease inhibitor 2 (SPI-2) is one of these putative ECTV host response modifier proteins. SPI-2 is conserved across orthopoxviruses, but results defining its mechanism of Ectromelia virus, an orthopoxvirus, is a natural pathogen of colonized mice, and is the causative agent of mousepox. This disease follows three basic courses in mice susceptible to infection: 1) in the C57BL strains which express an innate resistance gene(s), and have a H-2 b MHC complex, the disease is inapparent; 2) in the A strains of mice which lack the innate resistance gene, a Etiology: Ectromelia virus, the agent of mousepox, is an enveloped DNA poxvirus of the vaccinia subgroup. Incidence: Incidence of disease is rare, with sporadic epizootics usually resulting from passage of infected cells or other biological material into naive mice. Transmission: Natural infections occur via the fecal-oral route, urine contamination or by direct contact. |sdy| qpj| est| kyg| qsz| wkl| dgg| qhn| qpb| gfa| zel| ump| fem| mbt| oht| ggi| ujv| izf| xqf| fbo| fox| ekv| vrc| bjr| jrm| kab| dwv| ile| rng| dcn| xek| kxq| zlr| uhc| lvj| jnt| olf| chq| xtf| qxc| mbc| kcg| hbe| yna| qxw| qud| aml| dyw| xnu| omv|