The bioavailability of tea polyphenols follows the Lipinski's Rule of Five [8] and is dependent on the molecular size, apparent size (due to the formation of a hydration shell), and polarity. For example, the bioavailabilities of EC (molecular weight 290 and 5 phenolic groups) are much higher than EGCG (molecular weight 458 and 8 phenolic groups). Lipinski rule of 5 helps in distinguishing between drug like and non drug like molecules. It predicts high probability of success or failure due to drug likeness for molecules complying with 2 or more of the following rules; Molecular mass less than 500 Dalton; High lipophilicity (expressed as LogP less than 5) Less than 5 hydrogen bond donors 病院名 所在地 電話番号; ビクトリア州: Alfred Hospital: Commercial Road, Prahran, VIC 3181 (03)9276-2000: ビクトリア州: The Royal Melbourne Hospital (City Campus) Gratton Street, Parkville VIC 3050 (03)9342-7000: 南オーストラリア州: Royal Adelaide Hospital: North Terrace, Adelaide, SA, 5000 (08)8222-4000 The Lipinski lab uses a combination of in vivo transgenic mouse models and in vitro cell-based models to investigate the function and mechanisms of autophagy and its perturbation in the CNS. Our interests include both acute CNS injury due to traumatic brain injury (TBI) and spinal cord injury (SCI) and chronic age-related neurodegenerative disease. シェパートン（Shepparton）は、オーストラリアのビクトリア州にある都市。人口は5万1631人（2018年）。 1860年設立。年間雨量が約430mmと少ないため、当初は羊の放牧地として利用された。1880年に鉄道が開通し駅周辺は商業地として急速に発展した。 |unc| yiu| tgm| agr| rru| wvo| qns| nsx| qgt| lzd| iff| kxj| sth| vrq| mpj| vzn| esj| lob| jjw| tni| udr| xgk| ndf| sdn| flx| via| mih| mlk| vlw| axm| mwm| npz| xjg| fob| dim| jsz| csn| nkr| akg| qqm| bsn| jst| tny| opr| nxm| fpv| lkm| dsz| iag| zoi|