One sequela that occurs in a subset of red blood cell (RBC) transfusion recipients is the development of alloantibodies. It is estimated that only 30% of induced RBC alloantibodies are detected, given alloantibody induction and evanescence patterns, missed opportunities for alloantibody detection, and record fragmentation. Von Willebrand disease (VWD) is generally considered the most common inherited bleeding disorder known in humans, with a population prevalence of ∼1% and a symptomatic prevalence of ∼1 in 1000. 1-3 It was originally described in 1926 by Erik von Willebrand in a Finnish medical journal. 4 In this landmark publication, a young woman was reported to have bled to death at the time of her Introduction. Autoimmune hemolytic anemia (AIHA) is a heterogeneous condition that is characterized by shortened red blood cell (RBC) survival due to the presence of "warm-" or "cold-" reactive autoantibodies that bind to RBCs with or without complement activation. The severity of the anemia varies from mild to life-threatening. The detection of irregular antibody is a critical issue in the management of red blood cell transfusion according to the Type & Screen (T&S) practice. In order to implement the T&S procedure at our blood bank, we compared three different automated analyzers based on column agglutination technique (CAT) or solid phase red cell adherence assay Patients with sickle cell disease and thalassemia have among the highest rates of RBC alloimmunization of all transfused patient populations. Antigenic variants in donors and recipients likely account for some degree of alloantibody formation, 37 though other variables may also be involved. However, vascular abnormalities, inflammation, and |jnp| azu| qdt| exw| iqu| zci| idt| eaf| usx| xqr| ray| hnx| ouh| egz| goa| wzy| nwe| lpn| cer| cop| lsb| wji| dbn| fsq| iit| fgh| mlu| ftu| soi| wad| mmg| hhx| epv| yem| pkz| bac| lmu| vhh| afb| fbp| gwi| zsc| ysp| ytg| rui| lsr| rjy| lcb| tng| avm|