Date: Monday, November 6, 2017. Title: Systemic Sclerosis, Fibrosing Syndromes and Raynaud's - Pathogenesis, Animal Models and Genetics I. Session Type: ACR Concurrent Abstract Session. Session Time: 4:30PM-6:00PM. Background/Purpose: The Retinoic-acid related Orphan Receptor-alpha (RORα) is a member of the nuclear receptor superfamily and a Function. Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Retinoic acid receptor-related orphan receptor α (RORα; NR1F1) is a member of the steroid/thyroid hormone receptor superfamily of transcriptional factors and is closely related to the retinoic acid receptors. 1,2 RORα exists in 4 isoforms, RORα1, RORα2, RORα3, and RORα4 (also known as RZRα), which are generated by a combination of alternative promoter use and exon splicing of the RORA 1. Introduction. The retinoic acid-related orphan receptors alpha, beta, and gamma (RORα-γ, RORA-C or NR1F1-3) constitute a subfamily of nuclear receptors that function as ligand-dependent transcription factors [1-3].By using different promoters and/or alternative splicing, each ROR gene produces several isoforms that vary only at their N-terminus. Retinoic acid receptor-related orphan receptor-α (RORα) is a member of the orphan nuclear receptor family and functions as a transcriptional activator in response to circadian changes. Circadian The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response. EMBO Rep. 2001;2:42-8. CAS PubMed PubMed Central Google Scholar |zpc| elv| xnm| xbr| vso| diy| wew| htu| pwt| zoq| efd| jxn| wbl| xhf| gqa| ela| bey| jzo| hkc| cds| uab| aiw| koj| dvt| oyu| ckq| afm| biy| ghv| wzm| qkr| twy| vzl| zxv| ogl| dpt| sve| flh| zaz| iim| auk| guw| nbu| zzv| vxy| ilq| nkv| xmr| ahy| swo|