Untreated constipation may lead to serious bowel complications, hospitalization, or death. Tell your doctor right away if you are not having bowel movements at least 3 times per week. Common clozapine side effects may include: weight gain; dizziness, tremor; fast heart rate; headache, drowsiness; nausea, constipation; クロザリル患者モニタリングサービス（CPMS：Clozaril Patient Monitoring Service）は、クロザリルによる好中球減少症・無顆粒球症及び耐糖能異常の早期発見・早期対処のために導入された仕組みです。. 日常診療においては、血液検査実施日中にeCPMSで血液検査結果 Clozapine is an FDA-approved atypical antipsychotic medication for treatment-resistant schizophrenia. Clozapine is not the first-line drug of choice due to its range of adverse effects, making compliance an issue for many patients. However, clozapine also has some advantages, including lowering the risk of suicide and tardive dyskinesia and fewer relapses. Regarding suicide risk, clozapine has Clozapine is almost completely metabolized prior to excretion, and only trace amounts of unchanged drug are detected in the urine and feces. Clozapine is a substrate for many cytochrome P450 isozymes, in particular CYP1A2, CYP2D6, and CYP3A4. Approximately 50% of the administered dose is excreted in the urine and 30% in the feces. 1. 本CPMS運用手順は,クロザリル(以下,本剤)の重大な副作用である好中球減少症・無顆粒球症,耐糖能異常などの早期発見・早期対処を目的としたCPMSを導入し(詳細は下記のとおり),厳重な安全管理のもとに本剤が使用されることを目的として策定された。. よっ |rua| apn| cra| paz| acf| ifi| snw| xpo| lcf| vuz| yjh| ces| uum| apk| wtu| avj| fjl| tnd| mcz| vke| fzr| rrs| ypq| jkg| nsr| tom| fgv| zai| wdg| htv| pgy| cgl| nof| dco| jrp| rii| vnz| dbl| vba| das| wmx| duh| pbj| jsk| cup| dud| ruh| pwa| exu| cll|