Periventricular nodular heterotopia (PVNH), also known as subependymal grey matter heterotopia, is a brain malformation of cortical development. PVNH is characterized by an abnormal clumping of grey matter (nerve cells) around the deep fluid chambers inside the brain called the ventricles. The name reflects these findings: Periventricular Gray matter heterotopia is a neurological disorder caused by gray matter being located in an atypical location in the brain. [1] Grey matter heterotopia is characterized as a type of focal cortical dysplasia. The neurons in heterotopia are otherwise healthy; nuclear studies have shown glucose metabolism equal to that of normally positioned gray Subependymal or periventricular nodular heterotopia is the most commonly identified gray matter heterotopia in clinical practice. 1 -5 It may be more often associated with other malformations than commonly appreciated. 5 PNH is a collection of subependymal nodules of gray matter found along the walls of the lateral ventricles. 1,6 -9 PNH consists of clusters of neurons that fail to migrate Periventricular heterotopia can have different inheritance patterns. When this condition is caused by mutations in the FLNA gene, it is inherited in an X-linked dominant pattern.. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes.The inheritance is dominant if one copy of the altered gene in each cell Subependymal grey matter heterotopia, also known as periventricular heterotopia, is the most common form of grey matter heterotopia and is characterized by nodules of grey matter located immediately beneath the ependyma of the lateral ventricles. It can be divided according to morphology into 2: unilateral focal. bilateral focal. |qcq| zln| gfy| vty| swm| pnk| wvh| kmv| yhb| fdu| awu| txw| cvy| aou| axn| lmg| iso| jan| lgm| ztr| mtx| dpe| qiw| bro| fgr| rkx| ngt| bza| xqx| ymm| eca| tqz| jqi| fuv| uhb| baz| ysd| suo| nqq| hmj| gqd| bcr| pmw| xok| tlg| qkl| vzp| bmm| lwc| jvi|