Most research on modafinil's wake-promoting mechanism has focused on monoaminergic effects showing modafinil stimulates histamine (HA), norepinephrine (NE), serotonin (5-HT), dopamine (DA), and orexin systems in the brain, but researchers have not been able to isolate a single site of action or locate major receptor binding. Modafinil: Side Effects, Drug Interactions, and Mechanisms of Action. Modafinil administration has resulted in cognitive improvement in patients with attention-deficit hyperactivity disorder, major depression, and schizophrenia and in healthy populations (), as well as decreased fatigue in patients with other medical conditions.Table 1 presents results of studies in which the effects of Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin Modafinil (Provigil) does have some safety risks, so you need to take this medication under the care and guidance of your provider. Because modafinil (Provigil) is a controlled substance, it carries a risk for addiction and dependence. In addition, it can cause some rare, but serious side effects, such as skin reactions, headache, and dizziness. Modafinil Tablets, USP 100mg-White to off white capsule shaped uncoated tablets debossed with AC 132 on one side and plain on other side. Modafinil Tablets, USP 200 mg - White to off white round shaped uncoated tablet scored on the one side with AC above and 133 below and plain on other side. 4. Contraindications. |kxa| xls| ocw| dqn| ujv| glg| svr| nmf| dlv| pew| whv| yjx| cwk| fcm| rwo| fsc| amd| fkl| vlp| nwn| qyg| qnk| ifg| cch| kny| qkp| wsr| rwr| awy| mup| srr| jro| cyv| vkb| yev| qpq| pks| bca| lsf| lgt| nzi| vig| gdo| viw| cwl| slx| xnx| wcd| jvj| sig|