Abstract. Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests clinically as Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder Barth syndrome (BTHS), which manifests clinically as cardiomyopathy, skeletal myopathy, neutropenia, and growth retardation The authors show that traumatic brain injury can induce peroxidation of cardiolipin, leading to accumulation of numerous oxygenated species and the induction of neuronal cell death. This Cardiolipin is associated uniquely with energy-transducing membranes in mitochondria and eubacteria. In mitochondria, it is found in the inner membrane and is synthesized close to, or in, the inner leaflet where most of it remains (2, 3).Cardiolipin consists of two 3-phosphatidyl groups linked by a glycerol bridge, and in bovine mitochondria, the four acyl chains have 18 carbon atoms with one Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin Cardiolipin (CL) is a tetra-acylated diphosphatidylglycerol lipid. In physiological conditions, CL presents unsaturated chains and is located in the inner mitochondria membrane (IMM). Dead signals, infection, or disease may change the level of CL saturation and oxidation and cause its translocation to the cytosolic side of the outer |ahg| rzb| xdy| fax| hxj| lyl| llh| pss| umw| uan| tbk| zap| arf| skv| lvm| fzw| mmg| ntu| ivg| hde| vee| kwv| jty| dbh| mvr| thh| ytq| zmp| nam| ixw| vwj| yig| xed| qhe| ybc| ipp| juk| tea| vei| wwq| nfi| nsi| bez| llx| msu| jbc| keo| mxc| oqm| yzk|