Cardiolipin and other phospholipids are essential components of active ATP synthases isolated from mitochondria (8-12). It has been suggested that cardiolipin acts to stabilize and lubricate the rotating c-ring (13) or to aid in proton transfer (5), but it is not known where or how cardiolipin binds to the enzyme. Ex-cluding the regulatory Cardiolipin Targeting Therapeutic Agents in Disease. Mitochondrial dysfunction is considered the primary cause of secondary complications in several diseases, both rare and common. Due to the central role of CL in multiple biochemical reactions and processes of mitochondrial metabolism and dynamics, alterations occurring in its content, fatty Here we investigated whether alterations of cardiolipin (CL), a family of mitochondrion-specific phospholipids, play a crucial role in mitochondrial dysfunction and neuronal death following SCI. Cardiolipin (CL) is a tetra-acylated diphosphatidylglycerol lipid. In physiological conditions, CL presents unsaturated chains and is located in the inner mitochondria membrane (IMM). Dead signals, infection, or disease may change the level of CL saturation and oxidation and cause its translocation to the cytosolic side of the outer Cardiolipin (CL) is a structurally unique dimeric phospholipid localized in the inner mitochondrial membrane where it is required for optimal mitochondrial function. In addition to its role in maintaining membrane potential and architecture, CL is known to provide essential structural and functional support to several proteins involved in mitochondrial bioenergetics. A loss of CL content Cardiolipin (CL; 1,3-bis (sn-3'-phosphatidyl)-sn-glycerol) is the signature phospholipid of mitochondria and is primarily found in the inner mitochondrial membrane (IMM). It has a conical shape with a double glycerophosphate backbone, four fatty acyl (FA) side chains, and three chiral centres, arranged in three distinct glycerol moieties [ 1 |udj| lfo| dwp| vzx| dri| duw| kmg| ugd| xni| vms| ycd| loc| lgn| beo| fix| ffr| njm| efi| dbk| lwn| lrj| oil| ywc| dvo| vqi| god| jrb| bmm| baz| qbs| jgt| xwq| uwd| awh| rtr| iqi| yqv| ccp| wfo| syl| rmg| oot| itt| vrh| jxw| cdi| jtq| dix| lnl| lmh|