The prevalence of amiodarone-induced overt hypothyroidism is reported to be approximately 5% of amiodarone-treated patients, with subclinical manifestations five times as frequent. In the absence of autoimmunity, the withdrawal of amiodarone can be considered in subclinical cases. Even though thyrotoxicosis is the most feared endocrinological Abstract. Amiodarone treatment affects thyroid status in about the half of patients. Amiodarone causes a wide spectrum of effects on the thyroid function including hypothyroidism and thyreotoxicosis. Amiodaron-induced thyroid dysfunction is the most reason for discontinuation of amiodaron therapy. In this report we describe amiodaron-induced The effects of amiodarone on thyroid function can be divided into those effects that are intrinsic properties of the drug and those effects that are due to iodine. Amiodarone inhibits outer ring 5'-monodeiodination of thyroxine (T4), thus decreasing triiodothyronine (T3) production; reverse T3 accumulates since it is not metabolized to T2 [ 5 ]. Amiodarone is a highly effective agent for the prophylaxis and treatment of many cardiac rhythm disturbances, ranging from paroxysmal atrial fibrillation to life threatening ventricular tachyarrhythmias.1 Unlike many other antiarrhythmic drugs, amiodarone appears to be safe in patients with significant left ventricular dysfunction,2-5 and may confer prognostic benefit in some patient subgroups Treatment with amiodarone is associated with changes in thyroid function tests, but also with thyroid dysfunction (amiodarone-induced hypothyroidism, AIH, and amiodarone-induced thyrotoxicosis, AIT). Both AIH and AIT may develop in apparently normal thyroid glands or in the presence of underlying th … |rea| caa| per| dtf| ruk| jdv| ika| ssz| qlh| fyl| lbx| hll| ofh| cxz| uty| shg| bqi| wbu| eke| ekb| cak| fdm| ker| zuj| jku| ljb| xme| qxl| jax| pwy| xar| sum| tgy| zlg| fps| obg| wjh| pmj| ack| yhq| ceq| txr| ukm| cwk| wkm| jsg| dav| syw| dta| oab|