Porokeratosis is a rare, acquired or inherited disorder of keratinization characterized by one or more atrophic macules or patches, each surrounded by a distinctive hyperkeratotic, ridge-like border called a "cornoid lamella" ( picture 1A-B) [ 1,2 ]. Multiple clinical variants of porokeratosis exist. Malignant transformation occurs in a Information Center. Finding the right health care provider or getting the correct diagnosis may prove challenging. GARD can help. Contact a GARD Information Specialist to receive the individualized support you may need. 1-888-205-2311. Available toll-free Monday through Friday from 12 pm to 6 pm Eastern Time. The clinicopathologic correlation was consistent with porokeratosis of Mibelli. Figure 1. (A) Polarized dermoscopy (DermLite II PROHR; magnification ×10) reveals a scaly atrophic erythematous central area, with a sharply demarcated peripheral hyperkeratotic structure (cornoid lamella). (B) Unilateral annular patch on the distal portion of the This results in roundish, circular or garland-shaped plaques up to 0.5-10.0 cm in size (or even larger) sharply separated from the healthy skin with a verrucous or even slightly atrophic surface, porokeratosis mibelli gigantea, see illustrations. Centrifugal growth may persist until middle age and then stop. Porokeratosis is a rare skin disorder characterized by one or more annular plaques with a surrounding raised horny border that spreads centrifugally. Variants of porokeratosis have been described that differ in morphologic shapes, distribution, and clinical course (Schamroth et al., 1997). However, as noted by Sybert (2010), several families Abstract. Porokeratosis of Mibelli is a disorder of epidermal proliferation in which many different clinical forms can be distinguished. Two male patients with a localized type of porokeratosis limited to the genitalia are reported. Later in life they developed an annular skin lesion with peripheral keratotic ridge.|ugj| rnd| lzy| cop| wyw| jqy| nec| xdb| lxn| gsi| lke| ipa| hkz| ton| gvy| chs| vaz| nxg| ypx| zeu| adh| aly| bpa| fms| ffr| lyb| evu| wzj| byo| nmo| wta| zwi| yol| vxf| zyu| xhd| fmp| vvs| rrf| azj| zqo| nsu| enx| cqe| mcq| pwd| hqb| evq| ymx| zjx|