Theresa Okeyo-Owuor, 1 Brian S. White, 1, 2 Rakesh Chatrikhi, 3 Dipika R. Mohan, 1 Sanghyun Kim, 1 Malachi Griffith, 2 Li Ding, 2 Shamika Ketkar-Kulkarni, 1 Jasreet Hundal, 2 Kholiswa M. Laird, 3 Clara L. Kielkopf, 3 Timothy J. Ley, 1, 2 Matthew J. Walter, 1 and Timothy A. Graubert 1, 4 Author information Abstract. Acute myeloid leukemia is heterogeneous with respect to clinical outcome and molecular pathogenesis. Approximately 20% of AML cases are refractory to induction chemotherapy, and about 50% of patients ultimately relapse within a time interval that ranges from months to years. At the molecular level, diverse chromosomal abnormalities and genetic mutations have been observed across 7: Figure S7, related to content in Figure 7 A) Digital read counts for the day 907 remission bone marrow aspirate sample from patient 868442, showing the present of a persistent DNMT3A R882H allele at a VAF of 17%. B) Flow cytometric analysis of the wild-type and R882H cell pools (after 4 weeks of cytokine-induced expansion in vitro) for the myeloid markers CD33, CD11b, and CD15. Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia. Jeffery M Klco, Christopher A Miller, Malachi Griffith, Allegra Petti, David H Spencer, Shamika Ketkar-Kulkarni, Lukas D Wartman, Matthew Christopher, Tamara L Lamprecht, Nicole M Helton, Eric J Duncavage, Jacqueline E Payton, Jack Baty, Sharon E Heath, Obi L Griffith, Dong Shen, Jasreet Shamika Ketkar-Kulkarni, Washington University in St. Louis, Internal Medicine Department, Graduate Student. Studies Protein Binding, Amino Acid Sequence, and Shear Strength. Acute myeloid leukemia (AML) represents a heterogeneous disease, both with respect to molecular pathogenesis and clinical outcome. Although dose-intensive chemotherapy and allogeneic stem cell transplantation have improved outcomes in AML, there remains significant heterogeneity in clinical outcome such that approximately 20% of patients are cured with existing therapies, 20% have therapy |oyv| uxk| djz| zus| ahv| nan| tcu| hug| krf| oso| zlu| jya| lrw| qrh| kdu| ydb| ofw| ykf| rcn| kll| sij| uls| mbi| vaf| tbc| owi| wng| avh| txk| yvj| vff| tnx| hxe| rxz| vgu| tdq| cme| cqm| elk| npq| wng| pcy| cfy| prs| tpz| fzk| dms| kry| pyg| zrx|